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Friday, July 21, 2017

Watch out, Saliva Animals Containing Antibiotics Bacteria Immune



Expressing affection on pets can be done in many ways, such as stroking, tickling, kissing up. But especially for the kiss, you should think twice before doing so.

A new study from New Zealand found that the saliva of animals may be as a means of transmission of infections that are resistant to antibiotics in humans. The study, led by Professor Nigel French from Massey University analyzes the irrational use of antibiotics in animals is the cause.

Massey said, exposure to saliva of animals as a means of transmission of bacterial infections have been identified by the WHO as a major health problem and is growing. He emphasized the need for attention to the increase in the incidence of two types of antibiotic-resistant bacteria that commonly cause urinary tract infections.

These antibiotic-resistant infections found in almost all pets are spread through fluids and dirt. Animals such as dogs or cats to clean themselves by licking, that's why their saliva might be met also by the antibiotic-resistant bacteria.

"When the saliva of the human mouth, most likely to occur transmission of bacteria in there," said Massey.

So he insisted on the importance of avoiding the kiss with pets, including a lick on the face. If licks are at hand, then the person should also wash your hands immediately.

Previous studies have found, the animal licking at the mouth of the risk of gum disease in humans. This is because the transmission of bacteria from the saliva of animals to humans.

Information On Colon Cancer

About one in 6 cancer patients under the age of 50 has a genetic aptitude for cancer. In patients who are early on with colon cancer, hereditary conditions such as Lynch syndrome often appear to occur. This syndrome increases the risk of bowel cancer. According to US researchers, early detection of genetic factors like this offers the ability to fight colon cancer.


Information On Colon Cancer


Colon cancer research results


The study led by Heather Hampel (Ohio State University) took 450 patients. Their age was between 17 and 49 years. All of them were operated on colon cancer by 2013 or later. Hampel and her team discovered mutations in the genes of 72 patients. At about half it was the hereditary Lynch syndrome. From the syndrome itself, people do not experience any complaints until they get a form of cancer. These are then the same as the complaints of patients with non-inherited cancers.
About one third of the investigations found to be at higher risk due to their genetic disorder. The investigator said that it would have been important if they had previously been screened for this deviation.

The Lynch syndrome

Colon cancer develops in patients with Lynch syndrome at relatively young age, often before the 50th year of life. This is an important difference with non-hereditary forms of colon cancer which usually occur only later
Children of someone with the disorder have 50% chance of inheriting this genetic disorder
The risk of cancer varies from 25-75% depending on the type of mutation
Through a heredity study (DNA research) it can be determined with certainty whether someone has the condition

Multi-gene panel tests

The team has made a remarkable finding. Indeed, in some of the patients they discovered genetic mutations that are more often linked to other cancers. These individuals initially found that family history did not indicate that these mutations were present. Only after multi-gene panel tests were applied were the criteria found to correspond to the family history of patients. These tests can identify more individuals with genetic cancer gene mutations.

The research results in doubt the current screening for hereditary risk factors. Hampel once again stresses the importance of discovering at a young age whether there is a risk of (hereditary) hereditary cancer.

Thursday, July 20, 2017

Information On Pulmonary Hypertension (PH) According To The Study

Pulmonary hypertension (PH) is associated with increased pressure in the pulmonary artery. PH can have several causes and is often fatal. The prognosis for pulmonary hypertension is often worse than that for cancer. Scientific research into the disease remains important. Prof. Dr. Anton Vonk Noordegraaf of the VUmc explains this study.

Information on pulmonary hypertension (PH) according to the study


Are there any medications for treating pulmonary hypertension?

Currently there are medicines that significantly extend and improve life and quality of life. We make small steps forward, but are still far from cure, which causes a significant proportion of patients to progress, despite the drugs. The current medication is mainly aimed at widening vessels to reduce blood pressure. The disease also includes remodeling, thickening and deformity of the blood vessel wall, which also causes blood pressure increase. With the current medication, this remodeling is still insufficiently counteracted. We are trying to get a breakthrough there.

 What are the obstacles in doing scientific research?

It is extremely difficult to investigate in rare cases. This can only be if the patient population is concentrated and you work with foreign centers. We do that too, a global consortium has been established. Progression and progress can only be booked as pulmonary hypertension, and any other rare condition is treated centrally.

What do you expect in the long term for the treatment of pulmonary hypertension?

I expect it to be possible in the future to stabilize the disease in most patients. Healing will be very difficult. In addition, I hope that more donor lungs will be available so that my patients who retard therapy in the future can get a new lung in good time.

If you look more at short-term research, what findings are important?

In recent years, we have learned a lot about how to optimize the current medication in the treatment of this disease. In addition, we now know that rehabilitation helps patients in good shape. Each muscle contains a lot of iron. Pulmonary hypertension patients usually have a severe iron deficiency because their intestines do not absorb well. However, if you supplement the iron, it also strengthens the heart muscle. These are concrete solutions that you can already apply. Also, it is important that you do not allow the heart rate to increase too fast to prevent the heart from consuming too much oxygen. There are medicines to regulate that. Patients feel better and more objective and subjective. A point of attention is also the optimal care and guidance of the patients. Many patients suffer from anxiety disorders and depression. It requires a team approach to support these patients optimally.

Has progress been made in recent years?

Initially, we had no idea how and why that vessel wall so thickened; I think we have now fully understood the mechanism. The current path also provides points of action for drug development. Another point of concern is to strengthen and maintain the right ventricle to maintain high pressure in the pulmonary artery. The problem is often that the right ventricle becomes exhausted, resulting in heart failure. We understand better how these mechanisms work and can work to therapies that support the right heart room.

Wednesday, July 19, 2017

Crohn's Disease Information: Systems Of Crohn's Disease

The bacterial composition in the stool of Crohn's disease appears to be a predictor of disease activity. That's what researchers from Maastricht UMC + write in the scientific journal Scientific Reports. The current standard for monitoring patients with chronic intestinal disease is to perform endoscopy regularly. However, this technique is expensive, invasive and not entirely free from possible complications. Measuring microbial life in stools could possibly provide an efficient and patient-friendly alternative.

crohn's disease information: systems of crohn's disease

Live With Crohn's Disease


Chronic intestinal disorders, including Crohn's disease, have a significant impact on the quality of life, especially during periods that aggravate symptoms. Various bacterial species with names like Ruminococcus, Roseburia and Blautia appear to be present during that active period. "By determining the presence of these and other bacteria, we are compiling a profile and we can monitor the disease as it were," says Maastricht UMC + research director Dr. Daisy Jonkers. "Although further research is required, this method may in the future provide an efficient and patient-friendly alternative for the regular endoscopy." In addition, the Maastricht scientists also want to focus on research into changes in bacterial composition during the course of the time. This would allow you to see a worsening of the disease before.

What's Crohn's Disease?


Crohn's disease is a chronic inflammatory bowel disease. The disorder can be erratic with alternation of relatively quiet periods (so-called remission) and active periods with sudden worsening of complaints (abdominal pain, fatigue, blood loss). Patients must therefore regularly check with the specialist to get in time. An endoscopy can be considered for possible inflammation of the intestinal mucosa, an indicator that aggravates the disease. If needed, treatment with medication can help keep the symptoms under control. However, an endoscopy involves disadvantages, such as high costs and risk of complications. Researchers therefore seek new ways to monitor patients better.

Bacteria In Crohn's Disease


The Maastricht researchers studied the bacterial composition in the faeces of 71 patients with Crohn's disease. That ultimately yielded nearly 200 samples, of which 97 in the active period and 97 in the quiet period of the disorder. The bacterial composition of the samples was determined by analysis of present genetic material. A specific bacterial profile was found to distinguish between patients in the active phase and patients in the remission phase. This means that certain bacteria are more present in one period, but less in the other (and vice versa). In almost 80 percent of cases, a certain bacterial composition predicted whether a patient was in the active phase of the disease.

Tuesday, July 18, 2017

Information On Crohn's Disease

What Is Crohn's Disease?


Crohn's disease is a chronic inflammation of the gastrointestinal tract. The disease affects the mucous membrane of the intestinal wall and penetrates into the deeper layers of the intestinal wall. It is an autoimmune disease. Usually, the immune system protects against unwanted invaders (bacteria and viruses). In an autoimmune disease, the immune system sees healthy body tissue for intruders. As a reaction, your body makes antibodies and goes into attack. This causes an inflammation. The inflammation often occurs at the end of the small intestine and the onset of the large intestine.

Information On Crohn's Disease


Develop a Test for Crohn's Disease


With a view to new individual treatment methods, the results are positive, according to Sheikh. "Hopefully we can develop a test that will determine which subtype Crohn has a patient in the future. Then we can use a treatment specifically aimed at this subtype. "

Types Of Crohn's Disease


Sheikh and colleagues discovered two subtypes of the disease by analyzing the intestinal tissue of 21 patients. They saw that each of the types had a unique pattern in genetic engineering and with different visible properties. One type was in part comparable to the intestinal build-up of a 'healthy' patient. In the other type they saw a pattern in the genes that are typically characteristic of the ileum. This last part of the small intestine is also called the small intestine.

Can crohns disease be cured?


Patients who have Crohn often get the same treatment now. Because there is no treatment yet that permanently removes the cause, these are often medicines. These do not match anyone as well. According to researcher Sheikh, this is very plausible, as it could just be that they have a different subtype of the disease.

Monday, July 17, 2017

Information On COPD And Heart Failure

Given the overlap in risk factors (smoking, low movement and aging) heart failure and chronic lung disease COPD often occur jointly. Because the symptoms (shortness of breath, fatigue) are often similar, the distinction in practice is difficult. The common co-morbidity of these diseases remains unnoticed. In order to improve diagnosis and treatment of heart failure and COPD, closer cooperation between general practitioner, pulmonologist and cardiologist is required. E-health can be used for monitoring, coaching and the long-term screening of these patients.

Information On COPD And Heart Failure


To increase the responsibility and independence of patients and reduce the cost of treatment, e-health is used - especially complementary to existing care. Brunner-La Rocca believes that this is only the beginning of many possibilities of e-health. An example of this is a virtual nurse, who provides monitoring, coaching and feedback. E-health can also be part of the screening of the patient, thus contributing to the detection of conditions. According to Franssen, a note must be placed at the target group to be reached. "People who easily use apps or other applications are often already well-reachable. You just want to help the people who are the most difficult to manage. "Therefore, direct medical guidance will be needed.

COPD And Heart Failure Diagnosis


The doctors are convinced of the importance of better diagnostics. This task lies with specialists, but also general practitioners, who, according to Brunner-La Rocca, can have an umbrella function. It begins with consciousness and alertness. For the future, doctors expect clear guidelines, but for now a protocol for faster detection of co-morbidity is missing. Patients share risk factors such as smoking, low movement and high age. Also, one disease increases the risk to another. However, every heart patient investigates lung disorders or vice versa would be unprofitable. Therefore, therapists should primarily investigate the complaints. Often the diagnosed diagnosis does not explain the severity or combination of complaints. In case of suspicions of co-morbidity, further research is required and should be looked beyond the own department, and this is not always easy. Sometimes reasons such as lack of time or financial incentives do not refer to.

Cooperation is essential, but is currently in the hands of local initiatives, says Franssen. "It's just what an enthusiastic pulmonologist or cardiologist walks around." Wider set-up and regulated collaboration is the goal for the future. To this end, GPs, patient associations, insurers and specialists need to put their heads together. This is necessary according to Brunner-La Rocca. "We are talking about the relationship between two diseases, but there may also be five or ten. Multi-morbidity is becoming increasingly evolving with an aging population and cuts in care. "

Living With COPD And Heart Failure


Longarts Frits Franssen of the MUMC + saw many COPD patients whose degree of complaints was only partly explained by their reduced lung function. In further investigation, about 20 percent of patients with COPD also found heart failure. At the same hospital, cardiologist Hans-Peter Brunner-La Rocca addressed this same problem; High percentages of patients with heart failure were also found to have COPD. This has often been overlooked. After diagnosing the first diagnosis, another disease with the same symptoms is not immediately considered. According to Franssen, this is the pitfall. "Therefore, you should always think about whether complaints correspond to the diagnosed condition." If indeed co-morbidity occurs, complaints will not be resolved when both diseases are addressed. And that is very important for the patients. Brunner-La Rocca: "The quality of life is disproportionately affected in people with both conditions."

Saturday, July 15, 2017

Articles On Stress: Stress Affects The Body And Best Ways To Relieve Stress

We will perform better with short-term stress. However, if the stress becomes chronic, it can affect us in various adverse ways. Both in body and mind. When this chronic stress results in a burnout, the consequences are very significant.

articles on stress: stress affects the body and best ways to relieve stress


How Does Stress Affect The Body?


But stress does more. It also causes our body to make extra cortisol. This hormone prevents the extra (nor) adrenaline from exiting our body, causing the brain to absorb more sugar. With this sugar, the energy supply can be supplemented. Again, this situation should not take too long. Because in chronic stress, too much cortisol gets into the blood and affects our hormone condition. For example, our brains are less sensitive to the dopamine and serotinic lymphomas.

Too much cortisol affects the immune system and damages the hippocampus. This is the brain zone that drives emotions and memory. A prolonged production of extra cortisol (due to chronic stress) is so quite funest. Symptoms like insomnia, physical complaints and forgetfulness occur sooner.

articles on stress: stress affects the body and best ways to relieve stress


The difference between short-term stress, chronic stress and a burnout

Stress activates the amygdala, a small brain part at the left and right sleep. The amygdala is a type of alarm bell, which brings the body into stress in a state of readiness. In the case of overactive amygdala, our adrenal glands add additional hormones: adrenaline and noradrenaline. This translates into increased heart rate and faster breathing. In case of short-term stress this can not be harmful. On the contrary, these additional hormones keep us sharp, which usually makes us better.

In chronic stress, it becomes a completely different story. From prolonged stress we put ourselves out and can change the structure and functioning of the brain. The longer it takes, the harder we can turn the tide. Research shows that the part of the brain that promotes routine action is getting bigger. At the same time, the zones that drive innovative behavior are shrinking. This can lead to the stressed person becoming less inventive (and solution-oriented) and losing himself in automations. He or she continues to persevere in the behavior that has caused the stress and thus increases the risk of burnout.

A burn-out occurs especially in people who ignore the immune system warnings and continue to suffer. In case of excessive stress, our immune system produces signal substances that stimulate the brain to fatigue. If the stress lasts too long, fatigue will also take longer and waiting for the first signs of fatigue.

Best Ways To Relieve Stress: How To Control Stress?



articles on stress: stress affects the body and best ways to relieve stress

Healing can only be avoided by stopping stress and taking a lot of rest. And by setting less high demands on yourself. In that case, the number of stress hormones decreases automatically. Sometimes, however, the damage can not be repaired and fatigue, concentration problems and forgetfulness remain.